- Mouse Anti-CTLA4/CD152 Antibody
- MyBioSource.com
- Pricing InfoSupplier PageView Company Product Page
- MBS4380820
- 0.02 mg (With BSA & Azide at 0.2mg/ml)
- Human, Cow, Mouse, Rat
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
- Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
- Mouse
- 30-43kDa
- Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
- GRD4, CTLA-4, CELIAC3, CD, CD152, GSE, ALPS5, IDDM12
- Unconjugated
- IgG1 kappa
- L4P2F5.F10
- cytotoxic T-lymphocyte associated protein 4
- CTLA4/CD152
- Monoclonal
Specifications/Features
CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule